A Structural View on ESCRT-Mediated Abscission
نویسندگان
چکیده
منابع مشابه
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
Cytokinetic abscission, the final stage of cell division where the two daughter cells are separated, is mediated by the endosomal sorting complex required for transport (ESCRT) machinery. The ESCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular...
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Recently the ESCRT-III filamentous complex was designated as the driving force for mammalian cell abscission, that is, fission of the intercellular membrane bridge connecting daughter cells at the end of cytokinesis. However, how ESCRT-III is activated to set on abscission has not been resolved. Here we revisit the role of the upstream canonical ESCRT players ESCRT-II and CHMP6 in abscission. U...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2020
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.586880